In the Bristol team that discovered the “healing” protein. “Since I was a child, I have been passionate about science. The gender gap? Still a long way to go”


a Imperia Researcher In the university team for Bristol who discovered the Wound repair protein. It’s the 36 years old Silvia Cirillo From 10 years In the UK, Where he works every day in the field biological research.

The last days newsletter It is important published article On the magazine to know, can I have Major advances in the development of new therapies in regenerative medicine and the fight against cancer, rightly busy Pages of all major national newspapers, Because I’m doing well in the English workgroup Three Italian presences: behind – on the other side To Cirillo, Julia Pelia of Imperia (from Sardinia) H Eugenie Bedene (from Sicily).

ImperiaPost contact a doctor Silvia Cirillo For more details on study And understand what lies behind this great to work.

Healing protein: Silvia Cirillo from Imperia is one of the Bristol researchers

What is the object of your research?

Our laboratory treats Cell competition. let’s start with “Drovsilia” (insect) like animal model and several cell lines in which we study competetion.

In particular, the study that we have published, of which Julia Pena and Kasia Kozyrska They are the main authors, it is about p53. protein Also known as the “Guardian” of genome Because of this The ability to maintain stability in times of crisis. we have This protein has been found to be active in epithelial cells who have suffered ruin, For example a injury, and turn them into cells ‘Chief’ able to Direct the migration of neighboring cells for wound repair.

We dive into this study And if we can prove that these Mechanisms also occur in complex tissues We can use it Control cell migration and promote wound healing Who struggle to heal, like Ulcers or serious burns; Another important area in which there could be developments is that of tumors, Where is she Clumps of cells come together to form metastases. This study could lead to Develop new treatments to prevent metastases.

So there are several possibilities future applications It can improve people’s lives.

What is behind this wonderful work?

“A lot of effort and a lot of sweat. We had to publish this article More or less than 5 years It all started earlier. About 6 years ago another article was published where certain roles p.53 and refers to Results Interesting emerged from some experiences. So for the next five years we tried to Refine these findings and try to understand them better, Until this article is published.

How is your day?

“Every day I swear to myself Working “under the hood” (Under sterile conditions) to do experiences With cells trying to keep them alive in different situations, e Analyze the data obtained from the experiments. In my spare time, I devote myself sports, From football to climbing and cycling to my passion food”.

What is the most exciting part of your job?

“Definitely the times we see that The hypotheses we developed before confirming the experiments. Our job is to Attempts And she is tall satisfy When we see that they succeed. At the same time, the other side of the coin is frustration All the times we do not get the desired results.

How to get to Bristol Lab?

“after Diploma volume Banquet hall scientist Merger for Imperia I have He graduated from the University of for Pisa. After several experiences in Italy, including allCancer Research Institute of San Martino Hospital in Genoa, moved to UK, where I won PhD in Chemical and Biological Engineering from the University of Sheffield. After that I applied for full research workBristol University. At first I was in a lab Immunology And then I applied Eugenia Bedini’s studio.

Where does your passion for science come from?

“I have always had a passion to know. when I’m done middle school For me it was a clear choice Go to scientist, I already knew that I wanted to become biologist. High school allowed me to Acquire more knowledge from a scientific point of view.

It was always when he was a kid Stunned From science I looked Piero Angela, super quark. I remember in college, when we were introduced laws From Genetic I stayed electrified of this case.

The presence of women in research is becoming increasingly important. Is there still a long way to go to close the “gender gap”?

“He’s definitely still there. so much that Act, However it is important learn to know it’s The gender gap Existing And you do something for Processing. I work in University It is an environment Handsome From the standpoint moral And the full And the Open in each minority Whether ethnic, gender or LGBT. I consider myself fortunate, There’s a lot Warning for these subjects”.

And what about Italy?

“I’m almost now 10 years that I am not in Italy, So I don’t know exactly what it is continent. I know there’s not much money for To research Which is a shame because education And the Italian university Based on High quality”.

What is your relationship with Imperia?

i will come back when i can to be with me Parents It’s mine family, Generally Twice a year. Because pandemic Last Christmas I came back After two years I have not returned. I was rough. during the first complete closure you succeed About a month and a half of work at home to analyze the data. After that I always went to to work, or I can’t do my job in the lab. But it was still a period of isolation because of I was just living between home and workwithout other social interactions.

what is your dream?

“Keep doing what I’m doing, with hope in to come up Power for publication a goal In a similar way Importance Like this, but where my contribution Be my master. I hope to be there one day main author of a study May be useful for to improve the the life of people. public. »


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